The First and Second Part of Gangraena: or a Catalogue and Discovery of many of the Errors, Heresies, Blasphemies and pernicious Practices of the Sectaries (i.e. Independents like Thomas Goodwin-RB) of this time, vented and acted in England in these last four years, Also a particular Narration of divers Stories, Remarkable Passages, Letters; an Extract of many Letters, all concerning the present Sects; together with some Observations upon, and Corollaries from all the fore-named Premises (1646)

The second part even notes that it contains a "copy of a hymn sung by some Sectaries instead of David's Psalms;" and includes replies to some pamphlets (by Saltmarsh, Bacon, etc.) against the first part of Edward's work.

In short, this book is written to stay "the plague of Sectarianism," which Edwards writes, "rages more and more, putting forth the symptoms presaging death and destruction on both Church and State, if not timely prevented."