Calvin (on I John 2:18) writes, "Those that think that he (Antichrist) would be just one man, are dreaming! For Paul... plainly shows that it would be a body or a kingdom (II Thes. 2:3). He first foretells a falling away that would spread throughout the whole Church... Then he makes the head of this apostasy the adversary of Christ who would sit in God's temple and claim divinity and divine honours. Unless we deliberately want to err, let us learn to know Antichrist from Paul's description" (Cited in Nigel Lee, 666: Luther and Calvin's Doctrine of Antichrist: Antichrist in Scripture [Focus Christian Ministries, 1992], p. 58).

Wilkinson's book takes the classic Protestant position, called "historicism;" held by Luther, Calvin, Knox, the Westminster Divines, and most other Protestants, until the Jesuit inspired "futurist" and "preterist" systems began to gain ground, when Reformation hermeneutics waned.

Shows how Protestants prove that the Pope is that "Antichrist" and "man of sin" set forth in Scripture. Deals with the mystery of iniquity, the great apostasy, and practical applications of the doctrines examined.